What Is Punch Drunk Syndrome

What Is Punch Drunk Syndrome?

What Is Punch Drunk Syndrome?

Punch drunk syndrome, or dementia pugilistica, or boxer’s syndrome is also called chronic traumatic encephalopathy (CTE). This condition is common among boxers. It is caused by head trauma and the condition typically develops about 16 years after the initial head injury.

A patient with CTE develops tangles and threads in his or her brain that are similar to those found in the brains of Alzheimer’s patients. In its later stages, patients with CTE develop symptoms of dementia and Alzheimer’s disease.

What Is Punch Drunk Syndrome
What Is Punch Drunk Syndrome

Chronic traumatic encephalopathy (CTE), formerly known as dementia pugilistica or ‘punch drunk syndrome’, is described as a progressive neurodegenerative disease in people with a history of repetitive mild traumatic brain injury. The symptoms of CTE are extremely similar to those seen in other forms of dementia, particularly Alzheimer’s disease (e.g., cognitive impairment, memory loss, Parkinsonism, increasing confusion and disorientation, and slurred speech). As these clinical symptoms are shared with other neurodegenerative diseases, there’s currently no available test to diagnose the condition. At present, the most reliable way of confirming diagnosis of CTE is by examining post mortem brain tissue for certain changes.

To find out more, we spoke with Marc Goldfinger, a PhD student at Imperial College London (UK) about the disease. In this video, Marc provides us with a description of CTE, as well as a pathological demonstration illustrating the changes observed in post mortem brain tissues of individuals with CTE. He also talks us through his work with boxer’s brains, which focuses on a particular collection called the ‘Corsellis collection’.

A new study shows repeated blows to the head cause an increase of chemicals in the fluid that circulates around the brain and spinal cord. These chemicals are markers for brain and nerve cell injury. The rise of these chemicals of the brain may also help explain what is commonly known as “punch drunk” syndrome, with symptoms of long-term neurologic damage.
Punch Drunk Syndrome
Punch Drunk Syndrome
Researchers studied a group of amateur boxers and found those who had recently suffered repeated blows to the head during a recent boxing match had higher than normal levels of certain chemicals in their cerebrospinal fluid (fluid that circulates around the spinal cord and brain).

These chemicals, known as neurofilament light protein and total tau, have also been shown to be increased in some neurologic disorders with damage of brain neurons and cells.

Boxers and Brain Injuries

Researchers say about 20% of professional boxers develop chronic traumatic brain injury as a result of years of repeated blows to the head during their careers in the ring. But little is known about the brain injury risks faced by amateur boxers who must wear protective headgear and compete in shorter bouts.

In the study, published in the Archives of Neurology, researchers examined the cerebrospinal fluid of 14 amateur boxers within seven to 10 days after a boxing match and again three months later after the boxers had rested from boxing. Cerebrospinal fluid from 10 healthy, nonathletic adults was also analyzed for comparison.

The results showed that after a boxing match, the boxers had higher average levels of the brain chemicals neurofilament light protein and total tau than they did after three months with no boxing. These chemicals are used as markers of brain injury and damage to nerve cells of the brain.

In addition, they also had elevated levels of another protein, called glial fibrillary acidic protein, which indicates damage to a specialized type of brain cell. An increase in this protein has also been found in people who have experienced severe brain injury.

The study showed levels of all three of these chemicals were significantly higher in boxers who had sustained more than 15 blows to the head or experienced grogginess after the bout compared with those who had 15 or fewer hits to the head and no grogginess.Compared with the nonboxers, researchers found the boxers had higher levels of two of the three chemicals (neurofilament light protein and glial fibrillary acidic protein) immediately after a bout. Three months later, the boxers still had higher levels of neurofilament light protein than the control group.

Researcher Henrick Zetterberg, MD, PhD, of Göteborg University in Sweden, and colleagues say the findings provide scientific evidence to support the development of chronic symptoms also known as “punch drunk syndrome” in professional boxers.

What are the 4 stages of CTE?

Learn the symptoms in the four stages of CTE
  • Early on, symptoms include headaches as well as loss of attention and concentration.
  • “Executive dysfunction, memory loss, explosivity, and difficulty with attention and concentration” begin when those with CTE reach Stage III.

Who discovered punch drunk syndrome?

Dementia pugilistica, is commonly referred to as punchdrunk syndrome, due to the fact that it was originally discovered in boxers in the 1920s. A study published in 1928 in the Journal of the American Medical Association was the first to describe dementia pugilistica.

What are the early signs of CTE?

The symptoms of CTE include memory loss, confusion, impaired judgment, impulse control problems, aggression, depression, anxiety, suicidality, parkinsonism, and, eventually, progressive dementia. These symptoms often begin years or even decades after the last brain trauma or end of active athletic involvement.

Can you die from CTE?

Hockey player Bob Probert was found to have CTE after dying of heart failure at the age of 45. Scientists believe repeated head trauma can cause CTE, a progressive degenerative disease of the brain. Symptoms include depression, aggression and disorientation, but scientists can definitively diagnose it only after death.

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